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Determination of iron chelators used for therapy of iron overload disease.
Iron chelators are widely used in the treatment of iron overload disease. A therapeutic drug monitoring is indicated for the treatment of hereditary hemochromatosis (HH), which is a major source of transfusion-associated iron overload disease. In November 2011, the first pharmacokinetic parameters of an iron chelator to treat this patient population, deferasirox, were reported. The parameters were determined in a 50e0806aeb glynjarr
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